Get A calcium-based phantom bursting model for pancreatic islets PDF

By Richard Bertram, Arthur Sherman

Insulin-secreting β-cells, positioned in the pancreatic islets of Langerhans, are excitable cells that produce normal bursts of motion potentials whilst inspired via glucose. the program has been the point of interest of mathematical research for 2 many years, spawning an array of mathematical versions. lately, a brand new classification of types has been brought known as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which money owed for the wide variety of burst frequencies exhibited via islets through the interplay of multiple gradual procedure. right here, we describe one implementation of the phantom bursting mechanism during which intracellular Ca2+ controls the oscillations via either direct and oblique detrimental suggestions pathways. We express how the version dynamics may be understood via an extension of the fast/slow research that's usually hired for bursting oscillations. From this attitude, the version uses a number of levels of freedom to generate the whole variety of bursting oscillations exhibited by way of β-cells. The version additionally bills for quite a lot of experimental phenomena, together with the ever present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't really shortly an entire version of all β-cell houses, it demonstrates the layout rules that we expect will underlie destiny growth in β-cell modeling.

Show description

Read or Download A calcium-based phantom bursting model for pancreatic islets PDF

Best nonfiction_1 books

Extra resources for A calcium-based phantom bursting model for pancreatic islets

Example text

Rev. 54, 596–619. Worley, J. F. III, M. S. McIntyre, B. Spencer, R. J. Mertz, M. W. Roe and I. D. Dukes (1994). Endoplasmic reticulum calcium store regulates membrane potential in mouse islet β-cells. J. Biol. Chem. 269, 14359–14362. , P. Goforth, R. Bertram, A. Sherman and L. Satin (2003). The Ca2+ dynamics of isolated mouse β-cells and islets: implications for mathematical models. Biophys. J. 84, 2852–2870.

120, 307–322. Grodsky, G. M. (1989). A new phase of insulin secretion. How will it contribute to our understanding of β-cell function? Diabetes 38, 673–678. Henquin, J. C. (1998). A minimum of fuel is necessary for tolbutamide to mimic the effects of glucose on electrical activity in pancreatic β-cells. Endocrinology 139, 993–998. Keizer, J. and G. Magnus (1989). ATP-sensitive potassium channel and bursting in the pancreatic β cell. Biophys. J. 56, 229–242. Keizer, J. and P. Smolen (1991). Bursting electrical activity in pancreatic β cells caused by Ca2+ - and voltage-inactivated Ca2+ channels.

273, 10402–10410. , A. Gomis and M. Valdeolmillos (1995). The electrical activity of mouse pancreatic β-cells recorded in vivo shows glucose-dependent oscillations. J. Physiol. ) 486, 223–228. Santos, R. M. and E. Rojas (1989). Muscarinic receptor modulation of glucose-induced electrical activity in mouse pancreatic B-cells. FEBS Lett. 249, 411–417. Santos, R. , L. M. Rosario, A. Nadal, J. Garcia-Sancho, B. Soria and M. Valdeolmillos (1991). Widespread synchronous [Ca2+ ]i oscillations due to bursting electrical activity in single pancreatic islets.

Download PDF sample

A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman

by Thomas

Rated 4.60 of 5 – based on 26 votes